Origin and evolution of spliceosomal introns

IB Rogozin, L Carmel, M Csuros, EV Koonin - Biology direct, 2012 - Springer
Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

U1 snRNP telescripting: suppression of premature transcription termination in introns as a new layer of gene regulation

CC Venters, JM Oh, C Di, BR So… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Recent observations showed that nascent RNA polymerase II transcripts, pre-mRNAs, and
noncoding RNAs are highly susceptible to premature 3′-end cleavage and …

High-resolution expression map of the Arabidopsis root reveals alternative splicing and lincRNA regulation

S Li, M Yamada, X Han, U Ohler, PN Benfey - Developmental cell, 2016 - cell.com
The extent to which alternative splicing and long intergenic noncoding RNAs (lincRNAs)
contribute to the specialized functions of cells within an organ is poorly understood. We …

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

M Clarke, AJ Lohan, B Liu, I Lagkouvardos, S Roy… - Genome biology, 2013 - Springer
Abstract Background The Amoebozoa constitute one of the primary divisions of eukaryotes,
encompassing taxa of both biomedical and evolutionary importance, yet its genomic …

Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity

Y Marquez, M Höpfler, Z Ayatollahi, A Barta… - Genome …, 2015 - genome.cshlp.org
Alternative splicing (AS) diversifies transcriptomes and proteomes and is widely recognized
as a key mechanism for regulating gene expression. Previously, in an analysis of intron …

U1 snRNP telescripting regulates a size–function-stratified human genome

JM Oh, C Di, CC Venters, J Guo, C Arai… - Nature structural & …, 2017 - nature.com
Abstract U1 snRNP (U1) functions in splicing introns and telescripting, which suppresses
premature cleavage and polyadenylation (PCPA). Using U1 inhibition in human cells, we …

[图书][B] Understanding viruses

T Shors - 2017 - books.google.com
Understanding Viruses continues to set the standard for the fundamentals of virology. This
classic textbook combines molecular, clinical, and historical aspects of human viral diseases …

Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications

KJ Niklas, SE Bondos, AK Dunker… - Frontiers in cell and …, 2015 - frontiersin.org
Models for genetic regulation and cell fate specification characteristically assume that gene
regulatory networks (GRNs) are essentially deterministic and exhibit multiple stable states …

Genome-Wide Identification of the HMA Gene Family and Expression Analysis under Cd Stress in Barley

C Zhang, Q Yang, X Zhang, X Zhang, T Yu, Y Wu… - Plants, 2021 - mdpi.com
In recent years, cadmium (Cd) pollution in soil has increased with increasing industrial
activities, which has restricted crop growth and agricultural development. The heavy metal …

Draft genome sequence of the Antarctic green alga Chlamydomonas sp. UWO241

X Zhang, M Cvetkovska, R Morgan-Kiss, NPA Hüner… - Iscience, 2021 - cell.com
Antarctica is home to an assortment of psychrophilic algae, which have evolved various
survival strategies for coping with their frigid environments. Here, we explore Antarctic …