Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

Damage to organs by trauma, infection, diseases, congenital defects, aging, and other
injuries causes organ malfunction and is life-threatening under serious conditions. Some of …

Osteoarthritis (OA) is a major cause of pain and disability in the aging population, but its
pathogenesis remains incompletely understood. Alterations beneath the articular cartilage at …

Evidence has been building that the pathologic drive for development of osteoarthritis (OA)
involves more than simple mechanical “wear and tear.” Inflammatory mechanisms play an …

Owing to the rapid aging of society, the numbers of patients with joint disease continue to
increase. Accordingly, a large number of patients require appropriate treatment for …

Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …

Mesenchymal stem cells (MSCs) are pluripotent cells that can differentiate into multilineage
cell types, including adipocytes and osteoblasts. Mechanical stimulus is one of the crucial …

Abstract Symptomatic Slow Acting Drugs for Osteoarthritis (SYSADOA), such as hyaluronic
acid (HA), chondroitin sulfate (CS) and glucosamine (GlcN) are natural compounds …