The chiral oxazoline motif is present in many ligands that have been extensively applied in a
series of important metal-catalyzed enantioselective reactions. This Review aims to provide …

A prochiral (1, R2= H) or racemic (1, R2 6¼ H) carbonyl compound can be activated toward
electrophilic substitution via the formation of an enol or enolate intermediate, creating a …

N-Thiocyanatosaccharin (R 1) was readily prepared from the sweet additive Saccharin in
two steps with a 71% overall yield. By applying this new reagent to diverse nucleophiles …

Highly enantioselective chlorination of β-oxo esters and subsequent stereospecific
substitution of tertiary chlorides are described. Enantioselective chlorination of β-keto esters …

Novel bifunctional quaternary phosphonium bromides possessing an amide moiety were
designed for the highly enantioselective sulfenylation and chlorination of β-ketoesters under …

Stereoselective construction of chlorinated chiral carbon centers is a highly valuable
operation because the resulting chiral chlorides serve as versatile intermediates for …

Although quaternary onium salt-catalyzed phase-transfer reactions are generally believed to
require base additives, we discovered even without any base additives conjugate additions …

The efficient and enantioselective construction of cyclic compounds with a halogenated
tetrasubstituted carbon through various catalytic strategies remains challenging. Thus …

We report an enantioselective phase transfer α-chlorination of β-keto esters catalyzed by
hybrid amide-based Cinchona derivatives. The chlorination process proceeds with proper …

Highly modular chiral amino diol derivatives have been used as organocatalysts in the
enantioselective α‐chlorination of cyclic β‐keto esters. Optimization of the catalyst structure …