Introduction: Specificity protein (Sp) transcription factors (TFs) are members of the
Sp/Kruppel-like factor family, and Sp proteins play an important role in embryonic and early …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to
its aggressiveness and the challenge to early diagnosis and treatment. In recent decades …

Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic
cancer treatment. In this report we determined whether and how cerium oxide nanoparticles …

The oxidative stress-sensitive protein kinase Cδ (PKCδ) has been implicated in
dopaminergic neuronal cell death. However, little is known about the epigenetic …

Introduction: Survivin (SVN) is a member of the inhibitor of apoptosis (IAP) protein family that
promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated …

Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic
cancer treatment. Cerium oxide nanoparticles (CONPs) are currently being tested in pre …

Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of the transcription factor Sp1.
In the present study, we investigated whether pancreatic cancer treatment with a …

Curcumin (Cur) has been extensively studied in several types of malignancies including
colorectal cancer (CRC); however its clinical application is greatly affected by low …

B7-H4 is expressed in a variety of tumor cells and functions as a negative regulator of T
cells. However, clarification is needed as to whether B7-H4 mediates tumorigenesis through …

Tolfenamic acid lowers the levels of the amyloid precursor protein (APP) and amyloid beta
(Aβ) when administered to C57BL/6 mice by lowering their transcriptional regulator …