Imaging genetics and genomics research has begun to provide insight into the molecular
and genetic architecture of neural phenotypes and the neural mechanisms through which …

Imaging genetics offers the possibility of detecting associations between genotype and brain
structure as well as function, with effect sizes potentially exceeding correlations between …

Despite evidence of substantial comorbidity between psychiatric disorders and substance
involvement, the extent to which common genetic factors contribute to their co-occurrence …

Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …

Mental disorders represent an increasing personal and financial burden and yet treatment
development has stagnated in recent decades. Current disease classifications do not reflect …

The synaptic regulator, kalirin, plays a key role in synaptic plasticity and formation of
dendritic arbors and spines. Dysregulation of the KALRN gene has been linked to various …

A current survey and synthesis of the most important findings in our understanding of the
neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series …

Background Youths with family history (FH) of alcoholism are at greater risk of developing
alcohol use disorder (AUD); heightened impulsive behavior may underlie such increased …

Background Problematic alcohol use in adolescence and adulthood is a common and often
debilitating correlate of childhood attention-deficit/hyperactivity disorder (ADHD) …

Adequate control of impulsive urges to act is demanded in everyday life but is impaired in
neuropsychiatric conditions such as stimulant use disorder. Despite intensive research it …