The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …

The intestine is the largest interface between the internal body and the external
environment. The intestinal barrier is a dynamic system influenced by the composition of the …

In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has
been increasingly viewed as a significant modifiable risk factor for diseases such as …

A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of
cardiovascular diseases (CVD) including coronary heart disease, heart failure …

A poor diet is one of the leading causes for noncommunicable diseases. Due to the
increasing prevalence of overweight and obesity, there is a strong focus on dietary …

Given that obesity and associated disorder type II diabetes mellitus have reached epidemic
proportions worldwide, the development of efficient prevention and therapeutic interventions …

The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in
skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese …

A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in
response to changes in the intestinal microbiota through as-yet-unknown mechanisms …

Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The
impact of obesity on OA is driven by systemic inflammation, and increased systemic …