Therapeutic and diagnostic translation of extracellular vesicles in cardiovascular diseases: roadmap to the clinic
S Sahoo, M Adamiak, P Mathiyalagan, F Kenneweg… - Circulation, 2021 - Am Heart Assoc
Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …
secreted. The potential of exosomes as effective communicators of biological signaling in …
Human induced pluripotent stem cell–derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes
Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data
C Hu, T Li, Y Xu, X Zhang, F Li, J Bai… - Nucleic acids …, 2023 - academic.oup.com
Abstract CellMarker 2.0 (http://bio-bigdata. hrbmu. edu. cn/CellMarker or http://117.50.
127.228/CellMarker/) is an updated database that provides a manually curated collection of …
127.228/CellMarker/) is an updated database that provides a manually curated collection of …
Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair
Background: Advancing structural and functional maturation of stem cell–derived
cardiomyocytes remains a key challenge for applications in disease modeling, drug …
cardiomyocytes remains a key challenge for applications in disease modeling, drug …
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …
functional requirements of an adult. However, the key drivers of this process remain poorly …
Human pluripotent stem cell-derived atrial and ventricular cardiomyocytes develop from distinct mesoderm populations
The ability to direct the differentiation of human pluripotent stem cells (hPSCs) to the different
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Directed differentiation protocols enable derivation of cardiomyocytes from human
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …
Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker
SI Protze, J Liu, U Nussinovitch, L Ohana… - Nature …, 2017 - nature.com
The sinoatrial node (SAN) is the primary pacemaker of the heart and controls heart rate
throughout life. Failure of SAN function due to congenital disease or aging results in slowing …
throughout life. Failure of SAN function due to congenital disease or aging results in slowing …
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …
[HTML][HTML] Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes
Heart disease remains a major cause of death despite advances in medical technology.
Heart-regenerative therapy that uses pluripotent stem cells (PSCs) is a potentially promising …
Heart-regenerative therapy that uses pluripotent stem cells (PSCs) is a potentially promising …