Mass spectrometry is a highly complex analytical technique and mass spectrometry‐based
proteomics experiments can be subject to a large variability, which forms an obstacle to …

In the drug-discovery setting, the development of new peptide and protein-based
biopharmaceuticals attracts increased attention from the pharmaceutical industry and …

BACKGROUND For many years, basic and clinical researchers have taken advantage of the
analytical sensitivity and specificity afforded by mass spectrometry in the measurement of …

Cationic membrane-active peptides have been studied for years in the hope of developing
them into novel types of therapeutics. In this article, we investigate an effect that might have …

Protein or peptide sample losses could accompany all steps of the proteomic analysis
workflow. We focused on suppression of sample adsorptive losses during sample storage in …

Laser capture microdissection (LCM)-enabled region-specific tissue analyses are critical to
better understand complex multicellular processes. However, current proteomics workflows …

Peptide loss due to surface absorption can happen at any step in a protein analysis
workflow and is sometimes especially deleterious for hydrophobic peptides. In this study, we …

Obtaining maximal sensitivity of nano UHPLC-MS/MS methods is primordial to quantify
picomolar concentrations of neuropeptides in microdialysis samples. Since aspecific …

To comply with current proteomics guidelines, it is often necessary to analyze the same
peptide samples several times. Between analyses, the sample must be stored in such a way …

Protein and peptide adhesion is a major factor contributing to sample loss during proteomic
sample preparation workflows. Sample loss often has detrimental effects on the quality of …