The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …

Adenosine (Ado) accumulates in tissues under metabolic stress. On myocardial cells, the
nucleoside interacts with various receptor subtypes (A1, A3, and probably A2A and A2B) …

Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

Adenosine is released during tissue injury, ischemia and tumor growth, and promotes
angiogenesis. Because mast cells accumulate in the proximity of new blood vessel …

Adenosine is widely distributed in mammals. One of the primary roles of adenosine within
the cardiovascular system is to directly control the functions of both cardiac and vascular …

Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with
the use of some small-molecule kinase inhibitors and antibody-based therapies targeting …

Adenosine, formed primarily via hydrolysis of 5′-AMP, has been historically dubbed a
“retaliatory” metabolite due to enhanced local release and beneficial actions during …

Cells of the cardiovascular system generate and release purine nucleoside adenosine in
increasing quantities when constituent cells are “stressed” or subjected to injurious stimuli …

The relative roles of free-radical production, mitochondrial ATP-sensitive K+ (mitoKATP)
channels and possible receptor cross-talk in both opioid and adenosine A1 receptor (A1AR) …

The potential neuroprotective actions of the A 3 adenosine receptor (A 3 AR) were
investigated using mice with functional deletions of the A 3 AR (A 3 AR−/−) in behavioral …