A historical overview of protein kinases and their targeted small molecule inhibitors
R Roskoski Jr - Pharmacological research, 2015 - Elsevier
Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and
they can modify the function of a protein in almost every conceivable way. Protein …
they can modify the function of a protein in almost every conceivable way. Protein …
Organometallic and coordination rhenium compounds and their potential in cancer therapy
EB Bauer, AA Haase, RM Reich, DC Crans… - Coordination Chemistry …, 2019 - Elsevier
This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of
action in biological systems and their status in clinical trials. Biological studies of different …
action in biological systems and their status in clinical trials. Biological studies of different …
Ischemic cell death in brain neurons
P Lipton - Physiological reviews, 1999 - journals.physiology.org
This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …
global ischemia and focal ischemia. These are the two principal rodent models for human …
[HTML][HTML] Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
To understand the insulin-induced activation of 6-phosphofructo-2-kinase (PFK-2) of the
bifunctional enzyme PFK-2/fructose-2, 6-bisphosphatase in heart, the effect of …
bifunctional enzyme PFK-2/fructose-2, 6-bisphosphatase in heart, the effect of …
Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
XL Li, S Aou, Y Oomura, N Hori, K Fukunaga, T Hori - Neuroscience, 2002 - Elsevier
Leptin is well known to be involved in the control of feeding, reproduction and
neuroendocrine functions through its action on the hypothalamus. However, leptin receptors …
neuroendocrine functions through its action on the hypothalamus. However, leptin receptors …
cAMP-and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human …
E Butt, K Abel, M Krieger, D Palm, V Hoppe… - Journal of Biological …, 1994 - ASBMB
The vasodilator-stimulated phosphoprotein (VASP) is a major substrate for cAMP-dependent-
(cAK) and cGMP-dependent protein kinase (cGK) in human platelets and other …
(cAK) and cGMP-dependent protein kinase (cGK) in human platelets and other …
[HTML][HTML] Direct evidence for a β1-adrenergic receptor–directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy
R Jahns, V Boivin, L Hein, S Triebel… - The Journal of …, 2004 - Am Soc Clin Investig
Today, dilated cardiomyopathy (DCM) represents the main cause of severe heart failure and
disability in younger adults and thus is a challenge for public health. About 30% of DCM …
disability in younger adults and thus is a challenge for public health. About 30% of DCM …
Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats
R Bernabeu, L Bevilaqua, P Ardenghi… - Proceedings of the …, 1997 - National Acad Sciences
cAMP/cAMP-dependent protein kinase (PKA) signaling pathway has been recently
proposed to participate in both the late phase of long term potentiation in the hippocampus …
proposed to participate in both the late phase of long term potentiation in the hippocampus …
Assay of protein kinases using radiolabeled ATP: a protocol
CJ Hastie, HJ McLauchlan, P Cohen - Nature protocols, 2006 - nature.com
Protein kinase activity results in the incorporation of radiolabeled phosphate from [γ-32 P]
ATP into a peptide or protein substrate. The measurement of the amount of radioactivity …
ATP into a peptide or protein substrate. The measurement of the amount of radioactivity …
[HTML][HTML] Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.
K Fukunaga, L Stoppini, E Miyamoto… - Journal of Biological …, 1993 - Elsevier
Among the molecular mechanisms that have been proposed to contribute to long-term
potentiation in hippocampus are the activation and autophosphorylation of Ca2+/calmodulin …
potentiation in hippocampus are the activation and autophosphorylation of Ca2+/calmodulin …