Background: Urinary excretion of albumin indicates kidney damage and is recognized as a
risk factor for progression of kidney disease and cardiovascular disease. The role of urinary …

The serum albumin level is one of several clinical parameters of the status of general health.
There is a marked correlation between low albumin levels and the incidence of morbidity …

The aim of this study is to investigate the role of the proximal tubule in microalbuminuria in
the early stage of diabetic nephropathy. Diabetes was induced in male Sprague-Dawley rats …

Glomerular permselectivity in early stages of overt diabetic nephropathy. Background
Impairment of glomerular size selectivity has been demonstrated by the dextran-sieving …

Differential macromolecule clearances were used to elucidate the mechanism of proteinuria
in patients with diabetic glomerulopathy. Uncharged dextrans of graded size, combined with …

Persistent clinical proteinuria (ie, urinary protein excretion> 0.5 g/24 h) is an ominous
development in a person with diabetes. It eventually leads to a decline in the glomerular …

Characterization of cationic albumin in minimal change nephropathy. The presence of
isoalbumins with a less anionic charge than the normal protein (pI= 4.7) is the hallmark of …

One of the most important questions concerning diabetic nephropathy is the identification of
its onset. By the time the clinical diagnosis is madewith the appearance of proteinuria …

Early tubular alterations were studied in 53 children with insulin-dependent diabetes
mellitus (IDDM), 32 of whom were followed at regular 6-monthly intervals for 3 years. The …

Background: Controversy exists regarding occurrence and measurement of structural
variants of albumin in urine. In this study, we examined cross-reactivity of in vitro modified …