Arachidonic acid (AA) metabolism is critical in the initiation and resolution of inflammation.
Prostaglandin E2 (PGE2) and leukotriene B4/D4/E4 (LTB4/LD4/LTE4), derived from AA, are …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Tuberculosis is primarily a disease of the lung. Constant expression of cellular immunity in
this organ is required to control Mycobacterium tuberculosis growth, but this can also result …

A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

One-third of the global human population harbours Mycobacterium tuberculosis in dormant
form. This dormant or latent infection presents a major challenge for global efforts to …

Regulatory T-cells (Tregs) act at the interface of host and pathogen interactions in human
infectious diseases. Tregs are induced by a wide range of pathogens, but distinct effects of …

Objectives New tests are needed to overcome the limitations of existing immunodiagnostic
tests for tuberculosis (TB) infection, including their inability to differentiate between active TB …

T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique
transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family) …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …

Autoimmune diseases are driven by TH17 cells that secrete pro-inflammatory cytokines,
especially IL-17. Under normal physiological conditions, autoreactive T cells are suppressed …