In order to cure diseases efficiently with minimal side effects in sophisticated medicine,
eminent drugs must be selectively delivered to diseased parts and allow to work only there …

Conspectus This Account highlights the structural features that render 2′-deoxy-2′-fluoro-
arabinonucleic acid (FANA) an ideal tool for mimicking DNA secondary structures and …

Herein, we developed a photolabile spherical nucleic acid (PSNA) for carrier-free and near-
infrared (NIR) photocontrolled self-delivery of small-interfering RNA (siRNA) and antisense …

Deoxyribonucleic acid (DNA) hydrogels are a unique class of programmable, biocompatible
materials able to respond to complex stimuli, making them valuable in drug delivery, analyte …

The self-assembly of block copolymers is often rationalized by structure and microphase
separation; pathways that diverge from this parameter space may provide new mechanisms …

The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …

Gene therapy is a therapeutic option for mitigating diseases that do not respond well to
pharmacological therapy. This type of therapy allows for correcting altered and defective …

Nucleic acid therapeutics (NATs), such as mRNA, small interfering RNA or antisense
oligonucleotides are extremely efficient tools to modulate gene expression and tackle …

The therapeutic potential of small interfering RNAs (siRNAs) is limited by their poor stability
and low cellular uptake. When formulated as spherical nucleic acids (SNAs), siRNAs are …

Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein
site-specific intramolecular interactions determine overall structure. Proteins then …