The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

The nucleolus is the site of ribosome biogenesis, one of the most resource-intensive
processes in eukaryotic cells. Accordingly, nucleolar morphology and activity are highly …

It is well established that mutations in the canonical WNT-signalling pathway play a major
role in various cancers. Critical to developing new therapeutic strategies is understanding …

Shwachman-Diamond syndrome is a rare inherited bone marrow failure syndrome
characterized by neutropenia, exocrine pancreatic insufficiency, and skeletal abnormalities …

Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

BACKGROUND As a highly prevalent epidemic disease of potato, late blight caused by
Phytophthora infestans poses a serious threat to potato yield and quality. At present …

Drug response prediction is important to establish personalized medicine for cancer therapy.
Model construction for predicting drug response (ie, cell viability half-maximal inhibitory …

Background Biomarkers that reflect glioblastoma tumour activity and treatment response are
urgently needed to help guide clinical management, particularly for recurrent disease. As the …

Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis
that accommodates cell growth and division, and is characterized by nucleomorphometric …