Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Macrocyclic compounds have received increasing attention in recent years. With their large
surface area, they hold promise for inhibiting protein–protein interactions, a chemical space …

Covering: up to 2020 Treatment resistance and drug-induced refractory malignancies pose
significant challenges for current chemotherapy drugs. There have been increasing …

Following a rational design, a series of macrocyclic (“stapled”) peptidomimetics of 10Panx1,
the most established peptide inhibitor of Pannexin1 (Panx1) channels, were developed and …

The introduction of alkyne moieties into peptides remains in demand as it represents a
promising approach for further structural diversification of peptides. Herein, we describe the …

Several analgesic α-conotoxins have been isolated from marine cone snails. Structural
modification of native peptides has provided potent and selective analogues for two of its …

Introduction: Peptide toxins are potent and often exquisitely selective probes of the structure
and function of ion channels and receptors, and as such are of significant interest to the …