Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune
system. Their expression, activity, and subcellular localization are associated with the …

Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …

Cysteine proteases are important targets for the discovery of novel therapeutics for many
human diseases. From parasitic diseases to cancer, cysteine proteases follow a common …

The field of immunoengineering aims to develop novel therapies and modern vaccines to
manipulate and modulate the immune system and applies innovative technologies toward …

Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are
targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein …

Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in
endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic …

Introduction: Cysteine cathepsins are involved in the development and progression of
numerous inflammation-associated diseases such as cancer, arthritis, bone and immune …

Elevated expression of the cysteine protease Cathepsin S has been correlated with a
number of different cancer types in recent years. As tools have been developed to enable …

Fractalkine (FKN, CX3CL1) is highly expressed in a majority of malignant solid tumours.
Fractalkine is the only known ligand for CX3CR1. In this study, we performed an analysis to …