[HTML][HTML] Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies

A Yuan, RA Nixon - Frontiers in neuroscience, 2021 - frontiersin.org
Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease

Y Jung, JS Damoiseaux - Brain, 2024 - academic.oup.com
Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

[HTML][HTML] The inflammasome adaptor protein ASC in mild cognitive impairment and Alzheimer's disease

XO Scott, ME Stephens, MC Desir, WD Dietrich… - International journal of …, 2020 - mdpi.com
Mild cognitive impairment (MCI) is characterized by memory loss in the absence of dementia
and is considered the translational stage between normal aging and early Alzheimer's …

Association of plasma neurofilament light with small vessel disease burden in nondemented elderly: a longitudinal study

Y Qu, CC Tan, XN Shen, HQ Li, M Cui, L Tan, Q Dong… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Neurofilament light chain (NfL) is a promising predictive
biomarker of active axonal injury and neuronal degeneration diseases. We aimed to …

[HTML][HTML] Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively …

M Malek-Ahmadi, Y Su, V Ghisays, J Luo… - Alzheimer's Research & …, 2023 - Springer
Abstract Background Plasma neurofilament light (NfL) is an indicator of neurodegeneration
and/or neuroaxonal injury in persons with Alzheimer's disease (AD) and a wide range of …

Different clinical contexts of use of blood neurofilament light chain protein in the spectrum of neurodegenerative diseases

G Palermo, S Mazzucchi, A Della Vecchia… - Molecular …, 2020 - Springer
One of the most pressing challenges in the clinical research of neurodegenerative diseases
(NDDs) is the validation and standardization of pathophysiological biomarkers for different …

Association of serum biomarker neurofilament light concentration with post-stroke depression: a preliminary study

H Zhao, M Mo, C Miao, L Li, H Yang, Y Liu… - General hospital …, 2020 - Elsevier
Objective To investigate serum neurofilament light (sNfL) levels in acute ischemic stroke and
to assess whether sNfL are related to the severity of disease and a potential prognostic …

The potential of neurofilament light as a biomarker in Alzheimer's disease

Y Xiong, T Meng, J Luo, H Zhang - European neurology, 2021 - karger.com
Background: Alzheimer's disease (AD) is the most common neurodegenerative disease
characterized by progressive memory loss and cognitive impairment. In 2011, the National …

A systematic review of the association between amyloid-β and τ pathology with functional connectivity alterations in the Alzheimer dementia spectrum utilizing PET …

SA Hasani, M Mayeli, MA Salehi… - Dementia and Geriatric …, 2021 - karger.com
The association between functional connectivity (FC) alterations with amyloid-β (Aβ) and τ
protein depositions in Alzheimer dementia is a subject of debate in the current literature …

[HTML][HTML] Plasma neurofilament light chain: a biomarker predicting severity in patients with acute ischemic stroke

J Wu, D Wu, Y Liang, Z Zhang, L Zhuang, Z Wang - Medicine, 2022 - journals.lww.com
Neurofilament light chain (NfL) levels have proved to be a good biomarker in cerebrospinal
fluid (CSF) correlating with the degree of neuronal injury and neurodegeneration. However …