Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …

An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in
1969. Hcy is a sulfur containing amino acid derived from the essential amino acid …

Elevation in homocysteine (Hcy) level is associated with insulin resistance; however, the
causality between them and the underlying mechanism remain elusive. Here, we show that …

Silk sericin is a natural polymer produced by silkworm, Bombyx mori, which surrounds and
keeps together two fibroin filaments in silk thread used in the cocoon. The recovery and …

Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Nutrition plays an essential role in the regulation of optimal immunological response, by
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …

The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut
microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase …

Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases
many inflammatory mediators. The source of these mediators within adipose tissue is not …

Resistin, originally described as an adipocyte‐specific hormone, has been suggested to be
an important link between obesity, insulin resistance and diabetes. Although its expression …

Endothelial dysfunction induced by hyperhomocysteinemia (HHcy) plays a critical role in
vascular pathology. However, little is known about the role of endoplasmic reticulum (ER) …