The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Perhaps due in no small part to its historical mystique, mechanochemistry has been
shrowded in relative obscurity for quite some time. The successes of mechanochemistry in …

Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

The scale-up of mechanochemical methods could play a transformative role in making
manufacturing processes in the pharmaceutical industry greener by eliminating solvent use …

Research on covalent organic frameworks (COFs) has recently gathered significant
momentum by the virtue of their predictive design, controllable porosity, and long-range …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Grinding solid reagents under solvent-free or low-solvent conditions (mechanochemistry) is
emerging as a general synthetic technique which is an alternative to conventional solvent …

In recent years cocrystal formation has emerged as a viable strategy towards improving the
solubility and bioavailability of poorly soluble drugs. In this review the success of numerous …

Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules
and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the …