Increasingly, primary hypertension is being considered a syndrome and not a disease, with
the individual causes (diseases) having a common sign—an elevated blood pressure. To …

Aldosterone's role in the kidney and its pathophysiologic actions in hypertension are well
known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other …

Intracranial atherosclerosis is more prevalent in Asian patients, whereas extracranial
atherosclerosis is more common in individuals from western countries. The reasons for this …

Stroke remains the fifth leading cause of mortality in the United States with an annual rate of
over 128,000 deaths per year. Differences in incidence, pathogenesis, and clinical outcome …

Lipoprotein lipase (LPL) plays an important role in lipid metabolism by hydrolyzing
triglycerides in chylomicrons and very low density lipoproteins. An increasing number of …

Hypertension and obesity in the young population are major risk factors for renal and
cardiovascular events, which could arise in adulthood. A candidate-gene approach was …

The burden of stroke is disproportionately high in the South Asian subcontinent with South
Asian ethnicity conferring a greater risk of ischemic stroke than European ancestry …

The blood–brain barrier (BBB) has many important functions in maintaining the brain's
immune-privileged status. Endothelial cells, astrocytes, and pericytes have important roles in …

Abstract Purpose of Review Intracranial atherosclerosis (ICAS) is the most common cause of
stroke throughout the world. It also increases the risk of recurrent stroke and dementia. As a …

Purpose/Aim of the study: The aim of this review is to summarize the role of genetic variants
affecting mean platelet volume (MPV) and platelet count (PLT) leading to higher platelet …