[HTML][HTML] The role of il-13 and the type 2 immune pathway in covid-19: A review

J Sasson, GB Moreau, WA Petri Jr - Annals of Allergy, Asthma & …, 2023 - Elsevier
While much has been learned about SARS-CoV-2 since December of 2019, uneven global
vaccine distribution, rapid viral spread and variant evasion of preventative measures has led …

Comparing the cytokine storms of COVID-19 and pandemic influenza

LM Pacheco-Hernández… - Journal of interferon & …, 2022 - liebertpub.com
Emerging respiratory viruses are major health threats due to their potential to cause massive
outbreaks. Over the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has …

IL-4 receptor blockade is a global repressor of naïve B cell development and responses in a dupilumab-treated patient

JD Mountz, M Gao, DM Ponder, S Liu, CW Sun… - Clinical …, 2022 - Elsevier
Here, we report a case of atopic dermatitis (AD) in a patient who received biweekly doses of
dupilumab, an antibody against the IL-4 receptor α chain (IL-4Rα). Single cell RNA …

Dupilumab therapy in atopic dermatitis is safe during COVID‐19 infection era: a systematic review and meta‐analysis of 1611 patients

AE El‐Qushayri, MA Mahmoud, S Salman… - Dermatologic …, 2022 - Wiley Online Library
The aim of this meta‐analysis is to evaluate the safety of dupilumab use in the management
of atopic dermatitis (AD) during the current pandemic regarding the risk and the hazards of …

COVID-19 and its impact on common diseases in the allergy clinics

E Kocatürk, EM Abrams, M Maurer, J Mitri… - The Journal of Allergy …, 2023 - Elsevier
Coronavirus disease 2019 (COVID-19) is a highly contagious viral disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has various effects on …

Dupilumab use is associated with protection from coronavirus disease 2019 mortality: a retrospective analysis

AN Donlan, I Mallawaarachchi… - Clinical Infectious …, 2023 - academic.oup.com
We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19)
pathogenesis in a mouse model. To test relevance to human disease, we used electronic …

Optimizing topical management of atopic dermatitis

S Butala, AS Paller - Annals of Allergy, Asthma & Immunology, 2022 - Elsevier
Objective Provide a review of atopic dermatitis management, focusing on optimizing topical
therapy, creating a stepwise approach for treatment plans, and providing guidance on when …

Biologics for allergic and immunologic diseases

H Morita, K Matsumoto, H Saito - Journal of Allergy and Clinical …, 2022 - Elsevier
Biologics or molecularly targeted drugs are often highly effective for the treatment of allergic
diseases and other immunologic disorders, and they are relatively safe for short-term use as …

[HTML][HTML] Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells

C Bangert, N Alkon, S Chennareddy… - Nature …, 2024 - nature.com
Dupilumab, an IL4R-blocking antibody, has shown clinical efficacy for atopic dermatitis (AD)
treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck …

Safety and efficacy of dupilumab for the treatment of hospitalized patients with moderate to severe coronavirus disease 2019: a phase 2a trial

J Sasson, AN Donlan, JZ Ma… - Open Forum …, 2022 - academic.oup.com
Background Based on studies implicating the type 2 cytokine interleukin 13 (IL-13) as a
potential contributor to critical coronavirus disease 2019 (COVID-19), this trial was designed …