Optimal patient stratification is of utmost importance in the era of personalized medicine.
Prediction of individual treatment responses by functional ex vivo assays requires model …

Microfluidics has become an important tool to engineer microenvironments with high
precision, comprising devices and methods for controlling and manipulating fluids at the …

Three-dimensional (3D) in vitro cell and tissue culture models, particularly for the central
nervous system, allow for the exploration of mechanisms of organ development, cellular …

Organotypic brain slices are three-dimensional 150 µm–thick sections of a postnatal day 10
mouse and can be cultured for several weeks in vitro. In such brain slices the complex …

Mouse brain slices are one of the most common models to study brain development and
functioning, increasing the number of study models that integrate microfluidic systems for …

Traditional in vitro models and animal models often lack the physiological complexity or the
accuracy to obtain predictive responses that are clinically translatable to humans. With the …

Organotypic brain culture is an experimental tool widely used in neuroscience studies. One
major drawback of this technique is reduced neuronal survival across time, which is likely …

Cell migration is of great relevance to researchers studying development, wound healing,
the immune system and its responses and diseases associated with deregulated cell …

Brain metastasis is a major challenge for therapy and defines the end stage of tumor
progression with a very limited patients' prognosis. Experimental setups that faithfully mimic …

Current in vitro models used for physiological studies and drug development present several
drawbacks. They are not able to accurately replicate the in vivo architectures, morphologies …