A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …
the host through recognition of distinct molecules, known as pathogen-or damage …
Pyroptosis: mechanisms and diseases
P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …
innate immunity and disease. The research scope of pyroptosis has expanded with the …
Polyamines in cancer: integrating organismal metabolism and antitumour immunity
CE Holbert, MT Cullen, RA Casero Jr… - Nature Reviews …, 2022 - nature.com
The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …
The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …
genes that were later grouped into the family were already known at that time. Although it is …
Interaction between microbiota and immunity in health and disease
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …
development and function includes multifold interactions in homeostasis and disease. The …
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
KM Schneider, A Mohs, W Gui, EJC Galvez… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
Nutritional components in Western diet versus Mediterranean diet at the gut microbiota–immune system interplay. Implications for health and disease
C García-Montero, O Fraile-Martínez… - Nutrients, 2021 - mdpi.com
The most prevalent diseases of our time, non-communicable diseases (NCDs)(including
obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising …
obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising …
Microbiota-derived metabolites as drivers of gut–brain communication
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …
The intestinal microbiota fuelling metabolic inflammation
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …