Sample preparation is a major task in a regulated bioanalytical laboratory. The sample
preparation procedure significantly impacts assay throughput, data quality, analysis cost …

Fatty liver or nonalcoholic fatty liver disease (NAFLD), a problem of increasing clinical
significance and prevalence worldwide, is associated with increased risk for the …

Thyroid hormones are essential hormones for regulating growth and development in
humans and wildlife. Methods to monitor precise and low levels of these hormones in serum …

BACKGROUND: Most clinical chemistry laboratories measure free thyroxine (FT4) by an
analogue (direct) method. Nevertheless, the validity of analogue FT4 immunoassays has …

OBJECTIVES:: This study was designed to improve our previously developed tandem mass
spectrometry (MS/MS) method for free thyroxine (FT4) by enhancing sensitivity and …

Thyroid hormones (THs) play critical roles in the regulation of growth and development,
including brain development, in both humans and animals. Until recently, TH levels were …

A growing number of researchers are focusing their attention on the possibility that thyroid
hormone metabolites, particularly 3, 5-diiodothyronine (T2), may actively regulate energy …

Environmental toxicants that interfere with thyroid hormone (TH) signaling can impact growth
and development in animals and humans. Zebrafish represent a model to study chemically …

Thyroid hormones are essential hormones for regulating growth and development. Methods
to accurately monitor low-levels (ppb-ppt) of these hormones in serum are needed to assess …

Background Accurate and reliable measurement of human serum free thyroxine (FT4) is
critical for the diagnosis and treatment of thyroid diseases. However, concerns have been …