[HTML][HTML] Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

[HTML][HTML] Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles

J Tao, SF Chow, Y Zheng - Acta pharmaceutica sinica B, 2019 - Elsevier
Nanoparticles are considered to be a powerful approach for the delivery of poorly water-
soluble drugs. One of the main challenges is developing an appropriate method for …

3D printed orodispersible films with Aripiprazole

W Jamróz, M Kurek, E Łyszczarz, J Szafraniec… - International journal of …, 2017 - Elsevier
Three dimensional printing technology is gaining in importance because of its increasing
availability and wide applications. One of the three dimensional printing techniques is Fused …

Drug nanocrystals: Fabrication methods and promising therapeutic applications

IS Mohammad, H Hu, L Yin, W He - International journal of pharmaceutics, 2019 - Elsevier
The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …

[HTML][HTML] Injected nanocrystals for targeted drug delivery

Y Lu, Y Li, W Wu - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the
advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals …

[HTML][HTML] Formulation and development of oral fast-dissolving films loaded with nanosuspension to augment paroxetine bioavailability: In vitro characterization, ex vivo …

AH Elshafeey, RM El-Dahmy - Pharmaceutics, 2021 - mdpi.com
Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and
anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility …

[HTML][HTML] Enhanced intradermal delivery of nanosuspensions of antifilariasis drugs using dissolving microneedles: a proof of concept study

AD Permana, MTC McCrudden, RF Donnelly - Pharmaceutics, 2019 - mdpi.com
Conventional oral administration of antifilariasis drugs results in nonspecific targeting of the
drugs and the intradermal delivery of nanoparticles with sizes of< 100 nm could be used to …

Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole

F Man, Y Yang, H He, J Qi, W Wu… - Molecular Pharmaceutics, 2023 - ACS Publications
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …

Safety of nanosuspensions in drug delivery

L Wang, J Du, Y Zhou, Y Wang - Nanomedicine: Nanotechnology, Biology …, 2017 - Elsevier
Nanosuspension technology is currently undergoing dramatic expansion in pharmaceutical
science research and development. However, most of the research efforts generally focus …

Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo

A Tuomela, P Liu, J Puranen, S Rönkkö… - International journal of …, 2014 - Elsevier
Nanocrystal-based drug delivery systems provide important tools for ocular formulation
development, especially when considering poorly soluble drugs. The objective of the study …