Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low
molecular weight secreted by different cell types. They regulate intercellular communication …

Polymorphisms of interleukin-1β (IL-1β) are associated with an increased risk of solid
malignancies. Here, we show that stomach-specific expression of human IL-1β in transgenic …

Persistent inflammation is known to promote and exacerbate malignancy. Primary liver
cancer, mostly hepatocellular carcinoma (HCC), is a clear example of inflammation-related …

The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …

Hepatocellular carcinoma (HCC) is a frequent malignancy worldwide with a high rate of
metastasis. The hepatitis B and C viruses are considered major etiological factors …

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …

Histopathologic examination reveals that most human tumors are associated with diverse
immune cell infiltrates, but the roles of host reactions in disease pathogenesis and prognosis …

Abstract Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation
that plays a complex, and sometimes contrasting, role in different stages of cancer …

The tumor microenvironment has been largely studied as a dynamic system orchestrated by
inflammatory cells, including cancer cells, stroma as well as the extracellular matrix. It is …