[HTML][HTML] Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis)

F Gouin, T Noailles - Orthopaedics & Traumatology: Surgery & Research, 2017 - Elsevier
Tenosynovial giant cell tumor (TSGCT) is a rare benign tumor arising from joint synovia,
bursae and tendon sheaths. Their variable clinical presentation is related to variations in site …

[HTML][HTML] Best clinical management of tenosynovial giant cell tumour (TGCT): A consensus paper from the community of experts

S Stacchiotti, HR Dürr, IM Schaefer, K Woertler… - Cancer treatment …, 2023 - Elsevier
Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive, mesenchymal tumor
arising from the joints, bursa and tendon sheaths. TGCT comprises a nodular-and a diffuse …

Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial

WD Tap, H Gelderblom, E Palmerini, J Desai, S Bauer… - The Lancet, 2019 - thelancet.com
Background Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm,
overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no approved …

Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study

MJL Mastboom, E Palmerini, FGM Verspoor… - The Lancet …, 2019 - thelancet.com
Background Diffuse-type tenosynovial giant-cell tumour is a rare, locally aggressive, and
difficult-to-treat soft tissue tumour. Clinical and surgical outcomes depend on multiple …

Current systemic treatment options for tenosynovial giant cell tumor/pigmented villonodular synovitis: targeting the CSF1/CSF1R axis

M Brahmi, A Vinceneux, PA Cassier - Current treatment options in …, 2016 - Springer
Opinion statement Adequate surgical resection remains the treatment of choice for
tenosyovial giant cell tumor (TGCT). However, diffuse type TGCT (D-TGCT) is more difficult …

Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial

H Gelderblom, C Cropet, C Chevreau, R Boyle… - The Lancet …, 2018 - thelancet.com
Background Pigmented villonodular synovitis (alternatively known as diffuse-type giant cell
tumour) is a rare, locally aggressive tumour driven by a specific translocation resulting in the …

[HTML][HTML] Diffuse-type tenosynovial giant cell tumour: current treatment concepts and future perspectives

EL Staals, S Ferrari, DM Donati, E Palmerini - European Journal of Cancer, 2016 - Elsevier
At present, the optimal treatment strategy in patients with diffuse-type tenosynovial giant cell
tumour (D-TGCT) is unclear. The purpose of this review was to describe current treatment …

Management of tenosynovial giant cell tumor: a neoplastic and inflammatory disease

JH Healey, NM Bernthal… - JAAOS Global Research …, 2020 - journals.lww.com
Background: Patients with diffuse tenosynovial giant cell tumor (TGCT) face a high risk of
recurrence, progression, and disability. This systematic review assesses the recent evidence …

[HTML][HTML] Long-term clinical activity, safety and patient-reported quality of life for emactuzumab-treated patients with diffuse-type tenosynovial giant-cell tumour

PA Cassier, A Italiano, C Gomez-Roca… - European Journal of …, 2020 - Elsevier
Objectives This study investigated the safety, clinical activity and patient-reported outcomes
of patients with diffuse-type tenosynovial giant-cell tumour (dTGCT) of the soft tissue who …

The diffuse-type tenosynovial giant cell tumor (dt-TGCT) patient journey: a prospective multicenter study

NM Bernthal, G Spierenburg, JH Healey… - Orphanet journal of rare …, 2021 - Springer
Background Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm
arising from the synovium of joints, bursae, and tendon sheaths affecting small and large …