Epidemiology of the inherited cardiomyopathies
WJ McKenna, DP Judge - Nature Reviews Cardiology, 2021 - nature.com
In the absence of contemporary, population-based epidemiological studies, estimates of the
incidence and prevalence of the inherited cardiomyopathies have been derived from …
incidence and prevalence of the inherited cardiomyopathies have been derived from …
Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
[HTML][HTML] Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes
L Zhao, B Zhang - Scientific reports, 2017 - nature.com
Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients.
The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood …
The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood …
Small animal models of heart failure
C Riehle, J Bauersachs - Cardiovascular research, 2019 - academic.oup.com
Heart disease is a major cause of death worldwide with increasing prevalence, which urges
the development of new therapeutic strategies. Over the last few decades, numerous small …
the development of new therapeutic strategies. Over the last few decades, numerous small …
Clinical and mechanistic insights into the genetics of cardiomyopathy
MA Burke, SA Cook, JG Seidman… - Journal of the American …, 2016 - jacc.org
Over the last quarter-century, there has been tremendous progress in genetics research that
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …
Small and large animal models in cardiac contraction research: advantages and disadvantages
N Milani-Nejad, PML Janssen - Pharmacology & therapeutics, 2014 - Elsevier
The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …
also adjusting this pumping activity quickly depending upon sudden changes in the …
Minor hypertrophic cardiomyopathy genes, major insights into the genetics of cardiomyopathies
Hypertrophic cardiomyopathy (HCM) was traditionally described as an autosomal dominant
Mendelian disease but is now increasingly recognized as having a complex genetic …
Mendelian disease but is now increasingly recognized as having a complex genetic …
Calcium signalling: dynamics, homeostasis and remodelling
MJ Berridge, MD Bootman, HL Roderick - Nature reviews Molecular …, 2003 - nature.com
Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …
Modulation of cardiac contractility by the phopholamban/SERCA2a regulatome
EG Kranias, RJ Hajjar - Circulation research, 2012 - Am Heart Assoc
Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …
A comparative anatomic and physiologic overview of the porcine heart
PP Lelovas, NG Kostomitsopoulos… - Journal of the …, 2014 - ingentaconnect.com
Despite advances during the last 2 decades in every aspect of cardiovascular research
(interventional cardiology, cardiopulmonary resuscitation, and so forth), Western societies …
(interventional cardiology, cardiopulmonary resuscitation, and so forth), Western societies …