Building nanostructures with drugs

W Ma, AG Cheetham, H Cui - Nano today, 2016 - Elsevier
The convergence of nanoscience and drug delivery has prompted the formation of the field
of nanomedicine, one that exploits the novel physicochemical and biological properties of …

β-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: Stability, target-activated release and cytotoxicity

A Shapira, I Davidson, N Avni, YG Assaraf… - European Journal of …, 2012 - Elsevier
We studied a potential drug delivery system comprising the hydrophobic anticancer drug
paclitaxel entrapped within β-casein (β-CN) nanoparticles and its cytotoxicity to human …

An improved optical tweezers assay for measuring the force generation of single kinesin molecules

MP Nicholas, L Rao, A Gennerich - Mitosis: Methods and Protocols, 2014 - Springer
Numerous microtubule-associated molecular motors, including several kinesins and
cytoplasmic dynein, produce opposing forces that regulate spindle and chromosome …

Injectable gel self-assembled by paclitaxel itself for in situ inhibition of tumor growth

K Zhang, L Zhou, F Chen, Y Chen, X Luo - Journal of Controlled Release, 2019 - Elsevier
Injectable gels as a new avenue have demonstrated profound promise for the treatment of
cancers. However, the long-lasting but far-reaching challenge of in situ treatment of cancers …

Paclitaxel delivery system based on poly (lactide-co-glycolide) microparticles and chitosan thermo-sensitive gel for mammary adenocarcinoma treatment

JI Pesoa, MJ Rico, VR Rozados… - Journal of Pharmacy …, 2018 - academic.oup.com
Objectives To evaluate the combination of more than one release system in the same
formulation as a useful strategy to achieve paclitaxel delivery in a more sustained and …

Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy

H Salehi, L Derely, AG Vegh, JC Durand… - Applied Physics …, 2013 - pubs.aip.org
Confocal Raman microscopy, a non-invasive, label-free, and high spatial resolution imaging
technique is employed to trace the anticancer drug paclitaxel in living Michigan Cancer …

Three-dimensional microphase separation and synergistic permeability in stacked lipid–polymer hybrid membranes

M Kang, B Lee, C Leal - Chemistry of Materials, 2017 - ACS Publications
We present new structures of soft-material thin films that augment the functionality of
substrate-mediated delivery systems. A hybrid material composed of phospholipids and …

Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel

H Salehi, E Middendorp, I Panayotov… - … of biomedical optics, 2013 - spiedigitallibrary.org
Confocal Raman microscopy is a noninvasive, label-free imaging technique used to study
apoptosis of live MCF-7 cells. The images are based on Raman spectra of cells …

Effects of surface passivation on gliding motility assays

A Maloney, LJ Herskowitz, SJ Koch - PLoS One, 2011 - journals.plos.org
In this study, we report differences in the observed gliding speed of microtubules dependent
on the choice of bovine casein used as a surface passivator. We observed differences in …

Crystallization monitoring using simultaneous bright field and PlasDIC imaging

T El Arnaout, L Kurki, T Vaarala, K Ojala… - Chemical Engineering …, 2016 - Elsevier
Crystal size, shape and form are critical factors governing the quality and safety of
pharmaceutical products, with variation during crystal growth impacting downstream …