Current concepts and advances in graft-versus-host disease immunology
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …
Cytokines and costimulation in acute graft-versus-host disease
GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …
therapy for high-risk hematological malignancies, but the development of severe and/or …
Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was the first successful
therapy for patients with haematological malignancies, predominantly owing to graft-versus …
therapy for patients with haematological malignancies, predominantly owing to graft-versus …
The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease
M Koyama, GR Hill - Blood, The Journal of the American …, 2019 - ashpublications.org
Allogeneic stem cell transplantation is a cornerstone of curative therapy for high-risk and/or
advanced hematological malignancies but remains limited by graft-versus-host disease …
advanced hematological malignancies but remains limited by graft-versus-host disease …
A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis
GA Kennedy, SK Tey, L Buizen… - Blood, The Journal …, 2021 - ashpublications.org
We determined the efficacy of tocilizumab (TCZ) in preventing grade 2-4 acute graft-versus-
host disease (aGVHD) in patients with acute leukemia or myelodysplasia undergoing …
host disease (aGVHD) in patients with acute leukemia or myelodysplasia undergoing …
[HTML][HTML] GM-CSF: Master regulator of the T cell-phagocyte interface during inflammation
The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) was sequentially
redefined during the past decades. Originally described as a hematopoietic growth factor for …
redefined during the past decades. Originally described as a hematopoietic growth factor for …
The impact of inflammation on the immune responses to transplantation: tolerance or rejection?
MH Ravindranath, F El Hilali, EJ Filippone - Frontiers in Immunology, 2021 - frontiersin.org
Transplantation (Tx) remains the optimal therapy for end-stage disease (ESD) of various
solid organs. Although alloimmune events remain the leading cause of long-term allograft …
solid organs. Although alloimmune events remain the leading cause of long-term allograft …
Single-cell immune profiling reveals a developmentally distinct CD4+ GM-CSF+ T-cell lineage that induces GI tract GVHD
C Piper, E Hainstock, C Yin-Yuan, Y Chen… - Blood …, 2022 - ashpublications.org
Gastrointestinal (GI) tract involvement is a major determinant for subsequent morbidity and
mortality arising during graft-versus-host disease (GVHD). CD4+ T cells that produce …
mortality arising during graft-versus-host disease (GVHD). CD4+ T cells that produce …
Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease
Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease
(aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific …
(aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific …
CSF1R inhibition promotes neuroinflammation and behavioral deficits during graft-versus-host disease in mice
Chronic graft-versus-host disease (cGVHD) remains a significant complication of allogeneic
hematopoietic stem cell transplantation. Central nervous system (CNS) involvement is …
hematopoietic stem cell transplantation. Central nervous system (CNS) involvement is …