Background Per-and polyfluoroalkyl substances (PFAS) are of public health concern,
because of their ubiquitous and extremely persistent occurrence, and depending on their …

Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …

Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …

Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength,
leading to a progressively increased risk of fragility fractures. The global prevalence of …

As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …