The formation of carbon–carbon bonds is a quest that has required a lot of research
throughout the last 125 years of history of chemistry. The creation of these bonds is key to …

In past decades, interdisciplinary research has been of great interest for scholars.
Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry …

Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …

Sulfur contributes significantly to nature chemical diversity and thanks to its particular
features allows fundamental biological reactions that no other element allows. Sulfur natural …

The PIM kinase, also known as serine/threonine kinase plays an important role in cancer
biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. They are …

A series of bis-thiazoles 5a–g were synthesized from bis-thiosemicarbazone 3 with
hydrazonoyl chlorides 4a–g. Reaction of 3 with two equivalents of α-halocarbonyl …

Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

Cytosolic PIM kinases are the members of serine/threonine family play a crucial role in the
cancer progression and development. Overexpression of PIM kinases is observed in various …

Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their
anticancer and anti-inflammatory activities. The new compounds exhibited potent cytotoxicity …

Cancer is one of the life-threatening diseases accountable for millions of demises globally.
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …