Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …

The neurovascular unit (NVU) is a relatively recent concept that clearly describes the
relationship between brain cells and their blood vessels. The components of the NVU …

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …

To maintain energy supply to the brain, a direct energy source called adenosine
triphosphate (ATP) is produced by oxidative phosphorylation and aerobic glycolysis of …

Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and
glia, little is known of the contributions of these cells to the control of brain hemodynamics …

Diabetes mellitus (DM) is one of the primary pathological factors that contributes to aging-
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …

White matter microvascular alterations in temporal lobe epilepsy (TLE) may be relevant to
acquired neurodegenerative processes and cognitive impairments associated with this …

Pericytes are mural cells of the microvasculature, recognized by their thin processes and
protruding cell body. Pericytes wrap around endothelial cells and play a central role in …

Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …