Approaches and materials for endocytosis-independent intracellular delivery of proteins

N Chen, Y He, M Zang, Y Zhang, H Lu, Q Zhao… - Biomaterials, 2022 - Elsevier
The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …

Intracellular delivery of therapeutic proteins. New advancements and future directions

I Porello, F Cellesi - Frontiers in bioengineering and biotechnology, 2023 - frontiersin.org
Achieving the full potential of therapeutic proteins to access and target intracellular receptors
will have enormous benefits in advancing human health and fighting disease. Existing …

Proteomic analysis of circulating extracellular vesicles identifies potential biomarkers for lymph node metastasis in oral tongue squamous cell carcinoma

X Qu, TCN Leung, SM Ngai, SN Tsai, A Thakur, WK Li… - Cells, 2021 - mdpi.com
Lymph node metastasis is the most reliable indicator of a poor prognosis for patients with
oral tongue cancers. Currently, there are no biomarkers to predict whether a cancer will …

Shaping the future of oral cancer diagnosis: advances in salivary proteomics

O Barros, VG D'Agostino, L Lara Santos… - Expert Review of …, 2024 - Taylor & Francis
Introduction Saliva has gained increasing attention in the quest for disease biomarkers.
Because it is a biological fluid that can be collected is an easy, painless, and safe way, it has …

HCRP‑1 alleviates the malignant phenotype and angiogenesis of oral squamous cell carcinoma cells via the downregulation of the EGFR/STAT3 signaling pathway

Y Chen, L Hou - Oncology letters, 2022 - spandidos-publications.com
It has previously been reported that human hepatocellular carcinoma‑related protein 1
(HCRP‑1), which is a tumor suppressor gene, and epidermal growth factor receptor (EGFR) …

[HTML][HTML] AI illuminates paths in oral cancer: transformative insights, diagnostic precision, and personalized strategies

DU Kapoor, PK Saini, N Sharma, A Singh… - EXCLI …, 2024 - pmc.ncbi.nlm.nih.gov
Oral cancer retains one of the lowest survival rates worldwide, despite recent therapeutic
advancements signifying a tenacious challenge in healthcare. Artificial intelligence exhibits …

PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma

Z Abulaiti, L Chen, Q Xiao, A Aimaier… - Journal of Oral …, 2022 - Wiley Online Library
Objective This study aimed to explore the role of phospholipase C epsilon1 (PLCE1) in the
growth and progression of oral squamous cell carcinoma (OSCC) and determine its …

Comprehensive Characterization of Immune Landscape Based on Tumor Microenvironment for Oral Squamous Cell Carcinoma Prognosis

QL Li, J Mao, XY Meng - Vaccines, 2022 - mdpi.com
Objective: This study aims to identify an immune-related signature to predict clinical
outcomes of oral squamous cell carcinoma (OSCC) patients. Methods: Gene transcriptome …

Age-specific characteristics of head and neck second primary malignancies in patients treated for nasopharyngeal carcinoma: A retrospective study

Q Jiang, T Xu, M Zeng, Y He, Y Cai, Z Huang - International Journal of Oral …, 2024 - Elsevier
This study was performed to analyse the age-specific characteristics of head and neck
second primary malignancies (SPMs) in patients treated for nasopharyngeal carcinoma …

Saliva proteome-wide structural changes are associated with oral cancer aggressiveness

DC Granato, AGC Normando, CM Carnielli, LD Trino… - bioRxiv, 2023 - biorxiv.org
Diverse proteomics-based strategies have been applied to saliva to quantitatively identify
diagnostic and prognostic targets for oral cancer. Considering that these potential diagnostic …