The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and
cellular branches of the immune system, and they have important functions in the activation …

▪ Abstract T cell development is guided by a complex set of transcription factors that act
recursively, in different combinations, at each of the developmental choice points from T …

The activation threshold of cells in the immune system is often tuned by cell surface
molecules. The Fc receptors expressed on various hematopoietic cells constitute critical …

Interleukin-7 (IL-7), a product of stromal cells, provides critical signals to lymphoid cells at
early stages in their development. Two types of cellular responses to IL-7 have been …

Natural killer (NK) cells mediate the acute rejection of bone marrow cell (BMC) allografts, but
not solid tissue grafts, in lethally irradiated mice. However, the mechanisms underlying this …

Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote
engraftment, as well as the ability to elicit potent anti-tumor effects. However the clinical …

Mag is an MRL-derived glomerulonephritis susceptibility locus that includes the Fcgr2b and
Fcgr3 genes encoding the inhibitory Fc gamma receptor IIB (FcγRIIB) and active FcγRIII …

The activation threshold of various cells in the immune system is tuned by immune inhibitory
receptors. The inhibitory Fc receptor, FcγRIIB, is one of the critical elements for keeping …

Thymic progenitors have the capacity to generate αβ T cells, γδ T cells, and NK cells. To
determine whether these three lineages derive from a single precursor cell or from different …

Interleukin 7 (IL-7) is a pleiotropic cytokine which plays a role in both T and B cell function as
well as in establishment and maintenance of immunological barriers in epithelial tissues …