The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

Measuring biological age using omics data

J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

The landscape of aging

Y Cai, W Song, J Li, Y Jing, C Liang, L Zhang… - Science China Life …, 2022 - Springer
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

[HTML][HTML] Chronic inflammation and the hallmarks of aging

JJ Baechle, N Chen, P Makhijani, S Winer… - Molecular …, 2023 - Elsevier
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Gut microbiota and aging

Z Ling, X Liu, Y Cheng, X Yan, S Wu - Critical reviews in food …, 2022 - Taylor & Francis
Aging is characterized by the functional decline of tissues and organs and increased risk of
aging-associated disorders, which pose major societal challenges and are a public health …

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

JA Rusch, BT Layden, LR Dugas - Frontiers in endocrinology, 2023 - frontiersin.org
Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning

F Galkin, P Mamoshina, K Kochetov… - Aging and …, 2021 - ncbi.nlm.nih.gov
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …

Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder

M Lou, A Cao, C Jin, K Mi, X Xiong, Z Zeng, X Pan… - Gut, 2022 - gut.bmj.com
Objective Recent studies have provided insights into the gut microbiota in autism spectrum
disorder (ASD); however, these studies were restricted owing to limited sampling at the …