Nanoparticles for cancer therapy: current progress and challenges

S Gavas, S Quazi, TM Karpiński - Nanoscale research letters, 2021 - Springer
Cancer is one of the leading causes of death and morbidity with a complex pathophysiology.
Traditional cancer therapies include chemotherapy, radiation therapy, targeted therapy, and …

Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance

Y Yao, Y Zhou, L Liu, Y Xu, Q Chen, Y Wang… - Frontiers in molecular …, 2020 - frontiersin.org
Nanotechnology has been extensively studied and exploited for cancer treatment as
nanoparticles can play a significant role as a drug delivery system. Compared to …

Genetically engineered cell membrane–coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs

JH Park, Y Jiang, J Zhou, H Gong, A Mohapatra… - Science …, 2021 - science.org
As numerous diseases are associated with increased local inflammation, directing drugs to
the inflamed sites can be a powerful therapeutic strategy. One of the common characteristics …

Ligand‐installed nanocarriers toward precision therapy

P Mi, H Cabral, K Kataoka - Advanced Materials, 2020 - Wiley Online Library
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

Macrophages in atherosclerosis: a dynamic balance

KJ Moore, FJ Sheedy, EA Fisher - Nature Reviews Immunology, 2013 - nature.com
Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Targeting drug delivery in the vascular system: Focus on endothelium

PM Glassman, JW Myerson, LT Ferguson… - Advanced drug delivery …, 2020 - Elsevier
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

H Yan, X Duan, H Pan, N Holguin… - Proceedings of the …, 2016 - National Acad Sciences
Osteoarthritis (OA) is a major cause of disability and morbidity in the aging population. Joint
injury leads to cartilage damage, a known determinant for subsequent development of …

Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm

M Howard, BJ Zern, AC Anselmo, VV Shuvaev… - ACS …, 2014 - ACS Publications
Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Macrophages in vascular inflammation–from atherosclerosis to vasculitis

T Shirai, M Hilhorst, DG Harrison, JJ Goronzy… - …, 2015 - Taylor & Francis
The spectrum of vascular inflammatory disease ranges from atherosclerosis and
hypertension, widespread conditions affecting large proportions of the population, to the …

Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus

MA Bruckman, K Jiang, EJ Simpson, LN Randolph… - Nano …, 2014 - ACS Publications
The underlying cause of major cardiovascular events, such as myocardial infarctions and
strokes, is atherosclerosis. For accurate diagnosis of this inflammatory disease, molecular …