Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the RIβ-L50R variant is expressed

T Benjamin-Zukerman, V Pane, R Safadi-Safa… - bioRxiv, 2024 - biorxiv.org
Protein kinase A (PKA) is a crucial signaling enzyme in neurons, with its dysregulation being
implicated in neurodegenerative diseases. Assembly of the PKA holoenzyme, comprising a …