Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank

A Carrión-Castillo, C Boeckx - Scientific Reports, 2024 - nature.com
In this work we endeavor to further understand the genetic architecture of the cerebellum by
examining the genetic underpinnings of the different cerebellar lob (ul) es, identifying their …

Lung development genes, adult lung function and cognitive traits

M Talaei, S Waters, L Portas, BM Jacobs… - Brain …, 2024 - academic.oup.com
Lower lung function is associated with lower cognitive function and an increased risk of
dementia. This has not been adequately explained and may partly reflect shared …

Deciphering the genetic basis of behavioral traits in dogs: Observed-trait GWAS and latent-trait GWAS analysis reveal key genes and variants

M Mahmoodi, AA Mehrgardi, M Momen, JA Serpell… - The Veterinary …, 2024 - Elsevier
Dogs exhibit remarkable phenotypic diversity, particularly in behavioral traits, making them
an excellent model for studying the genetic basis of complex behaviors. Behavioral traits …

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

EP Tissink, AA Shadrin, D van der Meer… - Nature …, 2024 - nature.com
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from
one neuroimaging modality (eg structural, functional or diffusion magnetic resonance …

Genetic associations between bipolar disorder and brain structural phenotypes

MY Shang, CY Zhang, Y Wu, L Wang, C Wang… - Cerebral …, 2023 - academic.oup.com
Patients with bipolar disorder (BD) and their first-degree relatives exhibit alterations in brain
volume and cortical structure, whereas the underlying genetic mechanisms remain unclear …

The genetic architecture of cerebellar lobules: insights from the uk biobank

A Carriόn-Castillo, C Boeckx - bioRxiv, 2022 - biorxiv.org
In this work we take advantage of opportunities afforded by the UK Biobank, and
complement recent studies examining the genetics of cerebellar volume from that vantage …

Rare variant aggregation highlights rare disease genes associated with brain volume variation

DP Wightman, BAPC Maciel, RM Brouwer… - medRxiv, 2024 - medrxiv.org
Variation in brain volume is associated with common and rare disorders. Investigating the
genetics of brain volume may highlight overlap between diseases and biological …

A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremor

CE Castonguay, F Aboasali, M Medeiros, T Becret… - bioRxiv, 2024 - biorxiv.org
Essential tremor (ET) is a movement disorder characterized by an upper-limb postural and
action tremor. It is one of the most common neurological disorders, affecting 1% of the …

The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology

T Moberget, D van der Meer, S Bahrami, D Roelfs… - medRxiv, 2023 - medrxiv.org
The functional domain of the cerebellum has expanded beyond motor control to also include
cognitive and affective functions. In line with this notion, cerebellar volume has increased …

A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremor

G Rouleau, CE Castonguay, F Aboasali, M Medeiros… - 2024 - researchsquare.com
Essential tremor (ET) is a movement disorder characterized by an upper-limb postural and
action tremor. It is one of the most common neurological disorders, affecting 1% of the …