Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank
A Carrión-Castillo, C Boeckx - Scientific Reports, 2024 - nature.com
In this work we endeavor to further understand the genetic architecture of the cerebellum by
examining the genetic underpinnings of the different cerebellar lob (ul) es, identifying their …
examining the genetic underpinnings of the different cerebellar lob (ul) es, identifying their …
Lung development genes, adult lung function and cognitive traits
Lower lung function is associated with lower cognitive function and an increased risk of
dementia. This has not been adequately explained and may partly reflect shared …
dementia. This has not been adequately explained and may partly reflect shared …
Deciphering the genetic basis of behavioral traits in dogs: Observed-trait GWAS and latent-trait GWAS analysis reveal key genes and variants
Dogs exhibit remarkable phenotypic diversity, particularly in behavioral traits, making them
an excellent model for studying the genetic basis of complex behaviors. Behavioral traits …
an excellent model for studying the genetic basis of complex behaviors. Behavioral traits …
Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
EP Tissink, AA Shadrin, D van der Meer… - Nature …, 2024 - nature.com
Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from
one neuroimaging modality (eg structural, functional or diffusion magnetic resonance …
one neuroimaging modality (eg structural, functional or diffusion magnetic resonance …
Genetic associations between bipolar disorder and brain structural phenotypes
MY Shang, CY Zhang, Y Wu, L Wang, C Wang… - Cerebral …, 2023 - academic.oup.com
Patients with bipolar disorder (BD) and their first-degree relatives exhibit alterations in brain
volume and cortical structure, whereas the underlying genetic mechanisms remain unclear …
volume and cortical structure, whereas the underlying genetic mechanisms remain unclear …
The genetic architecture of cerebellar lobules: insights from the uk biobank
A Carriόn-Castillo, C Boeckx - bioRxiv, 2022 - biorxiv.org
In this work we take advantage of opportunities afforded by the UK Biobank, and
complement recent studies examining the genetics of cerebellar volume from that vantage …
complement recent studies examining the genetics of cerebellar volume from that vantage …
Rare variant aggregation highlights rare disease genes associated with brain volume variation
DP Wightman, BAPC Maciel, RM Brouwer… - medRxiv, 2024 - medrxiv.org
Variation in brain volume is associated with common and rare disorders. Investigating the
genetics of brain volume may highlight overlap between diseases and biological …
genetics of brain volume may highlight overlap between diseases and biological …
A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremor
CE Castonguay, F Aboasali, M Medeiros, T Becret… - bioRxiv, 2024 - biorxiv.org
Essential tremor (ET) is a movement disorder characterized by an upper-limb postural and
action tremor. It is one of the most common neurological disorders, affecting 1% of the …
action tremor. It is one of the most common neurological disorders, affecting 1% of the …
The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology
The functional domain of the cerebellum has expanded beyond motor control to also include
cognitive and affective functions. In line with this notion, cerebellar volume has increased …
cognitive and affective functions. In line with this notion, cerebellar volume has increased …
A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremor
Essential tremor (ET) is a movement disorder characterized by an upper-limb postural and
action tremor. It is one of the most common neurological disorders, affecting 1% of the …
action tremor. It is one of the most common neurological disorders, affecting 1% of the …