Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review

P Xie, HT Luo, WJ Pei, MY Xiao, FF Li, YL Gu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Gynostemma pentaphyllum (Thunb.) Makino (G.
pentaphyllum) can be used for both medicinal and tea and has lipid-lowering properties …

Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1

HS Lee, SM Lim, JI Jung, SM Kim, JK Lee, YH Kim… - Nutrients, 2019 - mdpi.com
Gynostemma pentaphyllum is widely used in Asia as a herbal medicine to treat type 2
diabetes, dyslipidemia, and inflammation. Here, we investigated the anti-obesity effect and …

Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

XY Liu, HW Zheng, FZ Wang, TW Atia… - Animal Models and …, 2024 - Wiley Online Library
In traditional Chinese medicine (TCM), based on various pathogenic symptoms and the
'golden chamber'medical text, Huangdi Neijing, diabetes mellitus falls under the category …

Gypenoside inhibits endothelial cell apoptosis in atherosclerosis by modulating mitochondria through PI3K/Akt/Bad pathway

N Song, L Jia, H Cao, Y Ma, N Chen… - BioMed Research …, 2020 - Wiley Online Library
Atherosclerosis remains the most common cause of deaths worldwide. Endothelial cell
apoptosis is an important process in the progress of atherosclerosis, as it can cause the …

Chromosome-level genome assembly of Gynostemma pentaphyllum provides insights into gypenoside biosynthesis

D Huang, R Ming, S Xu, J Wang, S Yao, L Li… - DNA …, 2021 - academic.oup.com
Abstract Gynostemma pentaphyllum (Thunb.) Makino is an economically valuable medicinal
plant belonging to the Cucurbitaceae family that produces the bioactive compound …

[HTML][HTML] Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice

M Song, D Tan, B Li, Y Wang, L Shi - Food Science and Human Wellness, 2022 - Elsevier
Gynostemma pentaphyllum, also called “Southern Ginseng” in China, is a traditional Asian
folk medicinal plant. Gypenosides (Gps) are the biologically active constituents of G …

Inhibitory effect of corosolic acid on α‐glucosidase: kinetics, interaction mechanism, and molecular simulation

M Ni, J Pan, X Hu, D Gong… - … of the Science of Food and …, 2019 - Wiley Online Library
BACKGROUND The suppression of α‐glucosidase activity to retard glucose absorption is an
important therapy for type‐2 diabetes. Corosolic acid (CRA) is a potential antidiabetic …

Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways

J Wang, M Zhao, X Cheng, Y Han, T Zhao… - Journal of agricultural …, 2019 - ACS Publications
Gynostemma pentaphyllum possesses neuroprotective bioactivity. However, the effect of
gypenosides on hypoxia-induced neural damage remains obscure. In this study, Gyp, the …

Ten New Dammarane-Type Saponins with Hypolipidemia Activity from a Functional Herbal Tea—Gynostemma pentaphyllum

M Yin, J Zhang, L Wang, F Li, Z Li, W Xiang, S Bie… - Molecules, 2020 - mdpi.com
Gynostemma pentaphyllum (thumb.) Makino is a functional herbal tea commonly used in
Asian countries and regions to reduce blood lipid levels. G. pentaphyllum saponin is the …

Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects

XH Meng, K Wang, T Chai, ZY Guo, M Zhao, JL Yang - Phytochemistry, 2020 - Elsevier
In this study, fourteen ingenane-type and nine jatrophane-type diterpenoids were isolated
from Euphorbia kansui, including seven undescribed compounds. Kansuingenol AC have …