Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

The evolutionary meaning and basic molecular mechanisms involved in the determination of
longevity remain an unresolved problem. Currently, different theories are on offer in …

The free radical theory of aging suggests that aging is caused by accumulation of damage
inflicted by reactive oxygen species (ROS). However, this concept has been very useful in …

Endothelial progenitor cells (EPCs) are mononuclear cells that circulate in the blood and are
derived from different tissues, expressing cell surface markers that are similar to mature …

Despite continued increases in human life expectancy, the factors determining the rate of
human biological aging remain unknown. Without understanding the molecular mechanisms …

Human aging can only be understood within its social and historical contexts. It is largely
determined by the complex interrelation of biological, cultural, social, political, and economic …

Age-related alterations in the bioenergetics of the heart and oxidative skeletal muscle
tissues are of crucial influence on their performance. Until now the prevailing concept of …

Vladimir Skulachev's coining of the term “phenoptosis” 25 years ago (Skulachev, VP,
Biochemistry (Moscow), 62, 1997) highlighted the theoretical possibility that aging is a …

BACKGROUND: The increase in the elderly poses problems in the areas of health, since it
can cause aging of the physiological function of organs. It also has an impact on kidney …

Abstract By 2050, population aged> 65 years is expected to be more than 2.5 times that of
the population aged 0–4 years. The onset of age-related ailments, such as …