LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

mRNAs, proteins and the emerging principles of gene expression control

C Buccitelli, M Selbach - Nature Reviews Genetics, 2020 - nature.com
Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Standardized annotation of translated open reading frames

JM Mudge, J Ruiz-Orera, JR Prensner, MA Brunet… - Nature …, 2022 - nature.com
To the Editor—Ribosome profiling (Ribo-seq) has extended our understanding of the
translational 'vocabulary'of the human genome, uncovering thousands of open reading …

[HTML][HTML] The coding capacity of SARS-CoV-2

Y Finkel, O Mizrahi, A Nachshon… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

Y Finkel, A Gluck, A Nachshon, R Winkler, T Fisher… - Nature, 2021 - nature.com
The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19.
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to …

Cellular functions of long noncoding RNAs

RW Yao, Y Wang, LL Chen - Nature cell biology, 2019 - nature.com
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Pervasive functional translation of noncanonical human open reading frames

J Chen, AD Brunner, JZ Cogan, JK Nuñez, AP Fields… - Science, 2020 - science.org
Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …

The plasticity of mRNA translation during cancer progression and therapy resistance

L Fabbri, A Chakraborty, C Robert, S Vagner - Nature Reviews Cancer, 2021 - nature.com
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

D Han, J Liu, C Chen, L Dong, Y Liu, R Chang… - Nature, 2019 - nature.com
There is growing evidence that tumour neoantigens have important roles in generating
spontaneous antitumour immune responses and predicting clinical responses to …

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …