G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

Obesity is one of the most prevalent health conditions in humans and companion animals
globally. It is associated with premature mortality, metabolic dysfunction, and multiple health …

The melanocortin receptor gene family consists of five single-exon members, which are
located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human …

A prolonged imbalance between a relative increase in energy intake over a decrease in
energy expenditure results in the development of obesity; extended periods of a positive …

The role of domestic mammals in the development of human biomedical sciences has been
widely documented. Among these model species the pig and dog are of special importance …

Incidence of overweight and obesity in dogs exceeds 30%, and several breeds are
predisposed to this heritable phenotype. Rapid progress of canine genomics and advanced …

黑素皮质素受体-4 (Melanocortin receptor-4, MC4R) 是5 种已发现的黑素皮质素受体家族成员
之一, 属于跨膜G-蛋白耦联受体超级家族, 对于调节动物的采食量, 体质量及能量稳态有着重要的 …

Abstract Melanocortin-4 receptor (MC4R), expressed abundantly in the hypothalamus, is a
critical regulator of energy homeostasis, including both food intake and energy expenditure …

Obesity is now the most common nutritional disorder in dogs and cats. 1 Numerous factors
can predispose an animal to obesity, including genetics, neutering, decreased activity level …

Obesity is an emerging health problem in purebred dogs. Due to their crucial role in energy
homeostasis control, genes encoding adipokines are considered candidate genes, and their …