▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

Inflammation is an integral part of the body's physiological repair mechanism, unless it
remains unresolved and becomes pathological, as evident in the progressive nature of …

Clonal composition and T cell receptor (TCR) repertoire of CD4+ and CD8+ T cells
infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with …

There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

Experimental autoimmune encephalomyelitis (EAE) is an animal model for autoimmune
central nervous system disease mediated by CD4 T cells. To examine the role of B cells in …

During the past several years, there has been enormous progress in the understanding of
the causative factors that initiate neuronal damage in various neurodegenerative diseases …

Stem cells are the natural units of embryonic generation, and also adult regeneration, of a
variety of tissues. Recently, the list of tissues that use the model of differentiation from stem …

Multiple sclerosis (MS) is a T cell-dependent chronic inflammatory disease of the central
nervous system. The role of chemokines in MS and its different stages is uncertain. Recent …

Myelin-specific T lymphocytes are considered essential in the pathogenesis of multiple
sclerosis. The myelin basic protein peptide (aa 83–99) represents one candidate antigen; …

Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …