Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves
an important scaffolding role at focal adhesions by recruiting structural and signaling …

p53 is known as the guardian of the genome and plays various roles in DNA damage and
cancer suppression. The p53 gene was found to express multiple p53 splice variants …

Both microgravity and radiation exposure in the spaceflight environment have been
identified as hazards to astronaut health and performance. Substantial study has been …

The p38 MAPK signaling pathway is essential in the cellular response to stress stimuli, in
particular in the endothelial cells that are major target of external stress. The importance of …

There is concern that degradation of vision as a result of space flight may compromise both
mission goals and long-term quality of life after space travel. The visual disturbances may be …

Background Previous studies have shown that the activation of p38MAPK signaling plays a
crucial role in regulating gonadal cell fate decisions in both mouse and human. Excessive …

Background: Quinic acid (QA), a natural compound found in fruits, for example in apple,
berries, and coffee beans, is a neutraceutical chiral compound used to synthesize new …

Radiation retinopathy (RR) is a major side effect of ocular tumor treatment by plaque
brachytherapy or proton beam therapy. RR manifests as delayed and progressive …

Radiation retinopathy is a serious vision-impairing complication of radiation therapy used to
treat ocular tumors. Characterized by retinal vasculopathy and subsequent retinal damage …

Aim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers.
However, potential role of QA derivatives against glioblastoma is not well established …