Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment
Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …
Characterization of conductivity changes during high-frequency irreversible electroporation for treatment planning
For irreversible-electroporation (IRE)-based therapies, the underlying electric field
distribution in the target tissue is influenced by the electroporation-induced conductivity …
distribution in the target tissue is influenced by the electroporation-induced conductivity …
Electrochemotherapy (ECT) and irreversible electroporation (IRE)-advanced techniques for treating deep-seated tumors based on electroporation
D Miklavcic, RV Davalos - Biomedical engineering online, 2015 - Springer
When a cell is exposed to a sufficiently intense electric field (for a sufficient duration), local
defects in the cell membrane appear and become permeable to molecules that otherwise …
defects in the cell membrane appear and become permeable to molecules that otherwise …
A comprehensive characterization of parameters affecting high-frequency irreversible electroporation lesions
T Miklovic, EL Latouche, MR DeWitt… - Annals of biomedical …, 2017 - Springer
Several focal therapies are being investigated clinically to treat tumors in which surgery is
contraindicated. Many of these ablation techniques, such as radiofrequency ablation and …
contraindicated. Many of these ablation techniques, such as radiofrequency ablation and …
Characterization of nonlinearity and dispersion in tissue impedance during high-frequency electroporation
Objective: The use of high-voltage, high-frequency bipolar pulses (HFBPs) is an emerging
electroporation-based therapy for the treatment of solid tumors. In this study, we quantify the …
electroporation-based therapy for the treatment of solid tumors. In this study, we quantify the …
Irreversible electroporation for the ablation of pancreatic malignancies: A patient‐specific methodology
Background and Objectives Irreversible Electroporation (IRE) is a focal ablation technique
highly attractive to surgical oncologists due to its non‐thermal nature that allows for …
highly attractive to surgical oncologists due to its non‐thermal nature that allows for …
System and method for ablating a tissue site by electroporation with real-time pulse monitoring
IIR Neal - US Patent 12,114,911, 2024 - Google Patents
A medical system for ablating a tissue site by electroporation with real-time pulse monitoring
during an electroporation treatment procedure is provided. The treatment control module …
during an electroporation treatment procedure is provided. The treatment control module …
Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
The present invention relates to the field of biomedical engineering and medical treatment of
diseases and disorders. Methods, devices, and systems for in vivo treatment of cell …
diseases and disorders. Methods, devices, and systems for in vivo treatment of cell …
Electrical characterization of human biological tissue for irreversible electroporation treatments
Irreversible electroporation (IRE) is a cancer therapy that uses short, high-voltage electrical
pulses to treat tumors. Due to its predominantly non-thermal mechanism and ability to ablate …
pulses to treat tumors. Due to its predominantly non-thermal mechanism and ability to ablate …
Methods for delivery of biphasic electrical pulses for non-thermal ablation
The present invention provides systems, methods, and devices for electroporation-based
therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the …
therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the …