Duchenne muscular dystrophy is a severe, progressive, muscle-wasting disease that leads
to difficulties with movement and, eventually, to the need for assisted ventilation and …

The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of
function mutations in the genes encoding dystrophin, or the associated proteins, triggers …

The maintenance of cellular function relies on the close regulation of adenosine
triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase …

Transmission of mechanical force is crucial for normal cell development and functioning.
However, the process of mechanotransduction cannot be studied in isolation from cell …

INTRODUCTION Along with its well-documented role as a track for cargo transport, the
microtubule (MT) cytoskeleton is linked to diverse structural and signaling roles in the …

The beating heart possesses intrinsic ability to adapt cardiac output to changes in
mechanical load. The century-old Frank-Starling law and Anrep effect have documented that …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Atomic Force microscopy (AFM) is becoming a prevalent tool in cell biology and biomedical
studies, especially those focusing on the mechanical properties of cells and tissues. The …