Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria
to acquire and develop an array of antibiotic resistance mechanisms. The sum of these …

Tetracyclines possess many properties considered ideal for antibiotic drugs, including
activity against Gram-positive and-negative pathogens, proven clinical safety, acceptable …

ST11 carbapenem-resistant K. pneumoniae (CRKP) has been the dominant clone in China.
In this review, we trace the prevalence of ST11 CRKP in China Antimicrobial Surveillance …

Background and Aim The emergence of colistin-resistant strains is considered a great threat
for patients with severe infections. Here, we investigate the prevalence and some possible …

Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for
the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and …

Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic
acid pharmacophore with potent inhibitory activity against K lebsiella p neumoniae c …

Eravacycline and comparators were tested against carbapenem-and tigecycline-resistant
Enterobacteriaceae and Acinetobacter isolates received at the United Kingdom's national …

Background: Carbapenems (CAR), colistin (CST), and tigecycline (TGC) alone or in
combination therapy has become the last-resort antibiotics for treating infections caused by …

Multidrug efflux pumps constitute a group of transporters that are ubiquitously found in any
organism. In addition to other functions with relevance for the cell physiology, efflux pumps …