Immunity to Cryptosporidium: insights into principles of enteric responses to infection
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …
cause of diarrhoeal disease in young children and in patients with primary and acquired …
Expansion microscopy of apicomplexan parasites
Apicomplexan parasites comprise significant pathogens of humans, livestock and wildlife,
but also represent a diverse group of eukaryotes with interesting and unique cell biology …
but also represent a diverse group of eukaryotes with interesting and unique cell biology …
Genetic crosses within and between species of Cryptosporidium
Parasites and their hosts are engaged in reciprocal coevolution that balances competing
mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but …
mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but …
[HTML][HTML] Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses
BE Haskins, JA Gullicksrud, BA Wallbank… - Mucosal …, 2024 - Elsevier
Cryptosporidium causes debilitating diarrheal disease in patients with primary and acquired
defects in T cell function. However, it has been a challenge to understand how this infection …
defects in T cell function. However, it has been a challenge to understand how this infection …
Transcriptional control of the Cryptosporidium life cycle
The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children,
and a cause and consequence of chronic malnutrition,. There are no vaccines and only …
and a cause and consequence of chronic malnutrition,. There are no vaccines and only …
Variant surface protein GP60 contributes to host infectivity of Cryptosporidium parvum
M Li, F Yang, T Hou, X Gong, N Li, LD Sibley… - Communications …, 2024 - nature.com
Biological studies of the determinants of Cryptosporidium infectivity are lacking despite the
fact that cryptosporidiosis is a major public health problem. Recently, the 60-kDa …
fact that cryptosporidiosis is a major public health problem. Recently, the 60-kDa …
Adaptations and metabolic evolution of myzozoan protists across diverse lifestyles and environments
RF Waller, VB Carruthers - Microbiology and Molecular Biology …, 2024 - journals.asm.org
Myzozoans encompass apicomplexans and dinoflagellates that manifest diverse lifestyles in
highly varied environments. They show enormous propensity to employ different metabolic …
highly varied environments. They show enormous propensity to employ different metabolic …
Genetic ablation of a female-specific apetala 2 transcription factor blocks oocyst shedding in Cryptosporidium parvum
The apicomplexan parasite Cryptosporidium is a leading global cause of diarrheal disease,
and the infection poses a particularly grave threat to young children and those with …
and the infection poses a particularly grave threat to young children and those with …
Cultivation, cryopreservation, and transcriptomic studies of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids
M Deng, T Hou, J Zhang, X Mao, F Yang, Y Wei… - Iscience, 2024 - cell.com
Cryptosporidium hominis and Cryptosporidium parvum are major causes of severe diarrhea.
Comparative studies of them are hampered by the lack of effective cultivation and …
Comparative studies of them are hampered by the lack of effective cultivation and …
Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell
Infection with the apicomplexan parasite Cryptosporidium is a leading cause of diarrheal
disease. Cryptosporidiosis is of particular importance in infants and shows a strong …
disease. Cryptosporidiosis is of particular importance in infants and shows a strong …