The nematode Caenorhabditis elegans is a powerful experimental setting for uncovering
fundamental tenets of nervous system organization and function. Its nearly invariant and …

Myriad mechanisms have evolved to adapt to changing environments. Environmental stimuli
alter organisms' physiology to create memories of previous environments. Whether these …

Classically, the zebrafish model organism has been used to elucidate the genetic and
cellular mechanisms related to development since the embryo forms and grows externally …

Aging is a prominent risk factor for neurodegenerative disease. Defining gene expression
mechanisms affecting healthy brain aging should lead to insight into genes that modulate …

Loss of cognitive function with age is devastating. EGL-30/GNAQ and G αq signaling
pathways are highly conserved between C. elegans and mammals, and murine Gnaq is …

The aging process is inherently complex, involving multiple mechanisms that interact at
different biological scales. The nematode Caenorhabditis elegans is a simple model …

We examined the effects of the extracts from two traditional Chinese medicine plants,
Cuscuta chinensis and Eucommia ulmoides, on the healthspan of the model organism …

Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying
mechanisms to restore memory function with age is critical. Using C. elegans associative …

Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-
characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform …

Several biogerontology databases exist that focus on genetic or gene expression data
linked to health as well as survival, subsequent to compound treatments or genetic …